MERIDIAN IMPLANT Designed to Minimize Fibrosis and Maximize Bone Integration

Fibrosis, or the formation of a fibrous capsule around an ceramic implant, is a known response to inert or dense materials such as zirconia. This capsule can act as a barrier between the implant and bone, compromising long-term stability.

 

Bioverit 1 – Osteoconductive, Not Inert

Unlike zirconia, which is chemically stable and biologically passive, Bioverit 1 is a bioactive. Its surface interacts with physiological fluids, leading to the spontaneous formation of a bone-like hydroxyapatite layer. This surface structure is highly compatible with bone tissue and facilitates direct structural integration, reducing the likelihood of soft tissue encapsulation.

 

A Favorable Environment for Natural Bone Growth

 

The surface of Bioverit 1 provides an osteoconductive scaffold that supports the attachment and growth of host bone cells. This process is governed entirely by the body's own regenerative capacity. No pharmacological, metabolic, or immunological action is exerted by the material itself.

 

Biocompatibility Reduces Unwanted Tissue Reactions

Because of its chemical similarity to mineralized bone, Bioverit 1 is well-tolerated by surrounding tissues. Its structure helps to minimize the occurrence of inflammation-related signals that are often associated with fibrous capsule formation in more inert materials.

 

Microstructured Surface Supports Mechanical Stability

The unique combination of glass and ceramic phases in Bioverit 1 results in a microstructured surface optimized for tissue contact. This structure provides a mechanical interlock with bone, promoting a stable and predictable integration without inducing fibrotic responses.

 

Accepted by the Body, Not Rejected

While some materials may be walled off by fibrous tissue, Bioverit 1 is structurally integrated into the bone through physicochemical compatibility. This contributes to improved long-term outcomes and a reduced risk of implant isolation.

Bioverit 1: Not stimulating the body – simply supporting it.
For a safer, scientifically proven alternative to inert ceramics –

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Meridian   – Step by Step

 

1. Surface Activation by Body Fluids

Upon contact with physiological fluids, the Glassbone surface interacts through ion exchange, releasing calcium and sodium ions. This process creates a localized environment favorable for natural tissue regeneration.

 

2. Silica Gel Layer Development

The Glassbone surface undergoes a controlled surface transformation, forming a thin silica-gel layer. This layer serves as a biocompatible interface for tissue attachment.

 

3. Formation of Bone-Like Surface Layer

On the silica layer, a carbonated hydroxyapatite (HCA) structure gradually forms. This is physicochemically similar to the mineral composition of native bone, promoting biological compatibility and integration.

 

4. Passive Binding of Endogenous Proteins

Due to its surface composition, the Glassbone material can adsorb proteins and signaling molecules naturally present in the surrounding tissue, without releasing any active substances. This supports a favorable environment for healing.

 

5. Supportive Scaffold for Cellular Colonization

The surface of Glassbone provides a stable scaffold to which endogenous host cells (e.g., osteoprogenitor and mesenchymal cells) can attach under physiological conditions. No cellular stimulation is induced by the product itself.

 

6. Matrix Deposition by the Host

Once host cells attach, they may produce extracellular matrix (ECM), such as type I collagen, enabling the natural formation of new bone tissue as part of the body’s normal remodeling process.

 

 

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