Superior Biocompatibility and Surface Reactivity

 

 

 

 

 

 

 

 

 

BIO-X®   shows excellent biocompatibility, minimal wear, and  no particle release, ensuring long-term stability and tissue compatibility.

It causes no ion release or galvanic reactions, and demonstrates a reduced risk of infection compared to metal and polymer implants.

 

 

 

 

 

 

 

 

 

 

 

 

 

Enhanced Osseointegration through Surface Layer

 Hydroxyapatite  significantly increased push-out strength, adhesive shear strength, and energy to failure, confirming a stronger and more reliable bone anchorage.

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Biofunctional Bone–Implant Interface

​The BIO-X®  forms an in-vivo hydroxy-carbonate apatite layer that binds directly to collagen fibers and osteoblasts.

Histology showed dense, direct bone integration without inflammation, in contrast to thicker bio-glass coatings that induced foreign-body reactions.

 

 

 Improved Hydrophilicity and Cell Adhesion

The bioactive surface dramatically increases wettability and osteoblast adhesion, accelerating early bone apposition and reducing variability in healing outcomes.

 

Low Inflammatory Response

 

BIO-X® showed no accumulation of inflammatory cells, 

This indicates a clean biological integration and long-term tissue compatibility.

 

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​Scientific Reports 2019, 9:16692

Institute of Orthopaedic Research and Biomechanics, University of Ulm

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